PDE6D MEDIATES TRAFFICKING OF PRENYLATED PROTEINS NIM1K AND UBL3 TO PRIMARY CILIA

Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice.In this study, we purified the prenylated cargo of PDE6D by affinity proteomics to gain insight into PDE6

Obesity has been suggested as a serious health problem.In many parts of the world, obesity is paradoxically associated with malnutrition.These problems are now so prevalent that they have replaced traditional problems such as malnutrition and infectious diseases.With the advancement of technology in the present century and the spread of motor pover